Abstract: abilities in the course“Intelligent Equipment Fault Diagnosis and Operation Maintenance”，this paper integrates the CDIO concept into teaching. Based on the goal of cultivating application-oriented talents，the course is restructured into four modules： Module 1 (Conceive) uses case videos and lab observation；Module 2 (Design) adopts blended teaching and case analysis；Module 3 (Implement) relies on experimental platforms and virtual simulation；Module 4 (Operate) involves experiments，data sharing， and enterprise collaboration. Teaching practice shows that this CDIO-based reform achieves“solid theory and hands-on practice”， significantly improving students’engineering practice，systematic thinking，and teamwork abilities，which meets the requirements of application-oriented undergraduate education.