Abstract: Aiming at the issues of frequent mechanical interference and prolonged debugging cycles in enterprise production line construction, as well as the challenges faced by some educational institutions where laboratory equipment fails to meet per capita requirements due to space constraints and funding shortages, this paper proposes a simulation design of the YL-36A equipment digital twin virtual practical platform based on NX MCD. Initially, the 3D simulation model is imported into the NX MCD module to establish the platform, with physical attributes and simulation sequences configured for the model's moving components. Subsequently, TIA Portal software is employed to design the platform's virtual-physical control program and HMI interface. Finally, PLCSIM Advanced V5.0 facilitates real-time data interaction between the NX MCD module's automation interface and virtual PLC, achieving coordinated operation between virtual and physical equipment. Simulation results demonstrate that utilizing virtual simulation software for program design and mechanical interference verification effectively eliminates common mechanical defects in physical production line construction while significantly reducing debugging time. This approach not only provides robust support for vocational colleges' experimental instruction but also offers valuable references for the digital transformation of production lines in small and medium-sized enterprises.